Research Associate I/II, Preclinical Research (Contract)
Lexeo Therapeutics
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- Location
- New York, NY
- Work style
- On-site
- Job type
- Contractor
- Posted
- Oct 15
- 5 days ago
Career path
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About the company
Lexeo Therapeutics
Biotechnology · 11 to 50 employees
What you'll do
- Generate and validate cellular knockdown and overexpression models
- Culture and maintain human iPSC-derived cardiomyocytes and other mammalian cell lines using aseptic technique
- Perform ddPCR, qPCR, conventional PCR, gel electrophoresis, Western blotting, and ELISA to support mechanism-of-action and target-validation studies
- Maintain complete and accurate laboratory records and contribute to the development and revision of assay SOPs
- Analyze experimental data and prepare concise summaries for Preclinical team
What you need
- Bachelor’s degree in cell biology, molecular biology, pharmacology, or a related field with 1-3 years of industry and/or academic lab experience
- Hands-on experience culturing iPSC and differentiation protocols for cardiomyocytes/neurons
- Hands-on experience with cellular transfection methods
- Experience with several of the following methods: ddPCR, qPCR, semi-quantitative PCR, Western blotting, ELISA, flow cytometry, and fluorescence microscopy
- Strong laboratory skills, rigorous record-keeping, attention to detail, and the ability to work effectively in a fast-paced environment
- Ability to work onsite 5 days/week at our New York City HQ
- Prior experience in an in vitro pharmacology group within the biotechnology or pharmaceutical industry
- Experience with high-throughput screening platforms, automation and workflows
- Experience with the Jess automated Western blotting platform
- Experience with TR-FRET, NanoBiT, FLIPR, or MEA assays
- Familiarity with engineered heart tissue models and cardiac biology
- Familiarity with AI-native, agentic lab-in-the-loop workflows connecting experimental design, automated execution, real-time data analysis, and iterative decision-making
- Demonstrated ability to generate, document, and communicate high-quality experimental results; publications or patents are a plus
Key skills
cellular assaysmolecular assaysassay developmenthigh-quality data
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Role Summary
The Research Associate I/II will support Lexeo’s human induced pluripotent stem cell–derived cardiomyocyte (iPSC-CM) platform, a core in vitro system used to evaluate target engagement, mechanism of action, and potency across discovery and preclinical programs. This hands-on laboratory role will execute established cellular and molecular assays, contribute to assay development, and generate high-quality data. The position reports to the Head of Cardiac Research and receives day-to-day scientific direction from the Preclinical Scientist leading the platform. This is an exciting opportunity to join a cutting-edge drug discovery team advancing new therapies for patients with genetic heart disease while gaining valuable experiences for a future career in biotech and medicine